Muhammad Ali vs. Floyd Patterson was a professional boxing match contested on November 22, 1965, for the WBC, NYSAC and The Ring championship.

[1] Patterson won the world heavyweight title in 1956, and became the first fighter to win it back in 1960 (after losing to Ingemar Johansson in 1959).

Patterson lost the title again in a 1962 fight against top contender Sonny Liston in a 1st-round knockout.

Meanwhile, Patterson went on to win fights against top contenders Eddie Machen and George Chuvalo.

Patterson lost by technical knockout at the end of the 12th round, going into the fight with an optimistic view.