Muhammad Ali vs. Floyd Patterson II was a professional boxing match contested on September 20, 1972, for the NABF championship.

After his decision victory over Oscar Bonavena in February 1972, Floyd Patterson signed to face fellow former heavyweight champion Muhammad Ali at Madison Square Garden on 28 August.

The two had faced off seven years earlier when Ali had dominated Patterson in a performance described as like watching someone "pulling the wings off a butterfly.

A series of hooks from Ali in the sixth caused swelling above Patterson's left eye which kept him on the back foot throughout the seventh as the eye swelled shut.

After the ringside doctor inspected eye between rounds, referee Arthur Mercante stopped Patterson from coming out for the eighth giving Ali a RTD (retired) victory.