[1] He was reelected to Ghana's Parliament in the 7 December 2012 General Elections, when he won the Kumbungu Seat.

Mumuni left parliament in 2004 when he became John Atta Mills' vice-Presidential running mate.

[2] Muhammad Mumuni had his basic education at the Kumbungu Local Authority Primary School between 1955 and 1960.

During the era of the Provisional National Defence Council government, he was a member of the Northern Regional Consultative Assembly.

[6] In the year 1994 to 1997, he was the chairman of the Board of Directors of Amasachina Self–help Association an indigenous NGO aimed at developmental projects in communities with the help of contribution, voluntary and communal labour.

[6] Mumuni was the President and a member of the Ghana Bar Association (Northern Region Branch) from 1992 to 1996.

Mumuni was the running mate of John Atta Mills in the 2004 Ghanaian presidential election.

[7] In February 2009, he was appointed by President Mills as the Minister for Foreign Affairs and Regional Integration, a position he continued to hold till 6 January 2013 when a new political cycle began.