He also serves as the chairman of the Centre for Responsible Leadership, a body of globally influential government, faith, media, business, and community leaders working together to solve the challenges facing humanity and the world today.

[24] In February 2020, Al-Issa led a delegation of Islamic scholars to visit Srebrenica in Bosnia to pay respect at the Srebrenica-Potocari Genocide Memorial Centre.

The Hajj is the largest gathering of Muslims in the world and Dr Al-Issa used the opportunity to advocate a moderate message of Islam promoting harmony and compassion.

[27] His address further asked Muslims "not to give any mind to those who are insolent, have ulterior motives, or seek to obstruct him" in a bid to promote tolerance and understanding.

The forum underscored that attempts to gain religious, cultural, political and economic advantages without respect for rights or ethics, and through forms of extremism, arrogance and racism, must be opposed.

Al-Issa was also instrumental in arranging an historic gathering of Iraqi religious leadership in the holy city of Makkah that aimed at promoting greater understanding and initiating comprehensive dialogue between the differing adherents of Islam.

In June 2021, Al-Issa and the Muslim World League spearheaded a meeting of religious and political leadership from Afghanistan and Pakistan in the holy city of Makkah that devised a roadmap for attaining lasting peace in the war-torn country.

[31] Following a full-day conference, an accord was signed that defined religious parameters to achieve a just and comprehensive peace and reconciliation process in Afghanistan in line with Islamic principles.

The Charter was formulated to create a pan-Islamic set of principles that support anti-extremism, religious and cultural diversity, tolerance and legislation against hate and violence.

Early in 2022, Dr Al-Issa laid the foundation of Faith For Our Planet, a global inter-faith coalition of environmentalists, religious leaders bureaucrats, politicians, and researchers.

Since June 2022, FFOP has initiated a series of workshops aimed at engaging religious and community leaders in addressing climate change and environmental degradation.

These workshops have been held in cities such as Islamabad, London, Banjul, Dhaka, and Kigali, training over 250 diverse stakeholders to lead faith-based climate action in their communities.

[33][34][35][36][37] In January 2023, FFOP launched the world's first-ever global Youth Interfaith Fellowship on Climate Change in partnership with the Duke Divinity School.

The fellowship, offered on an annual basis, is a fully funded residential program focusing on vocational training and capacity building for impact-driven faith-based climate action.

[38] NewsTalk Florida called it a “flagship initiative”, adding that it would help “thirty young leaders find solutions to the world's most pressing climate concerns over an intense one-week program".

The event focused on how religious giving can potentially unlock substantial resources exceeding a trillion dollars to bridge the global climate financing gap.

[47] Founded by the MWL and the Nahdlatul Ulama, the R20 platform was adopted as the first official engagement group on religion in the G20, making the R20 Summit the first religious gathering of its kind.

The two-day event brought together more than 400 participants, including 160 inter-religious figures from 20 of the world's largest economies, to discuss contemporary global challenges and the role religious leaders needed to play to address them.

Headed by Dr Amra Sabic-El-Rayess, Teachers’ College Associate Professor of Practice, the lab aims to foster a culture of resilience, serving as a center of excellence for research, leadership, and training.

During his trip, Dr Al-Issa engaged with the British Parliament, delivering a lecture on the Islamic and human values encompassed in the Charter of Makkah, as well as the Monarchy, making him the first prominent Muslim figure to be received by King Charles III at Buckingham Palace following his ascension to the throne.

It concluded with the establishment of a London-based independent body, including a Fatwa and religious guidance committee, and approved the Charter of Makkah for training Muslim Imams in Europe.

These meetings focused on cooperation for promoting interfaith peace-building efforts, confronting hate speech, and criminalizing acts that insult any religious sanctity.

During the visit, Sheikh Al-Issa worked to bring points of view closer and to talk with officials in India about the Islamic community and the importance of their rights.

Since taking over the Muslim World League in 2016, Dr Al-Issa has received a number of awards and recognitions from a wide range of prominent international institutions and government officials.