[citation needed] Mukesh Mohamed has sung some songs including "Vaa Saamy" in Annatthe.
Abdul Kadar, who was also a musician, trained Mukesh Mohamed to sing some of the toughest classical songs sung by the legendary playback singers[5] including K. B. Sundarambal, T. R. Mahalingam, T. M. Soundararajan and Sirkazhi Govindarajan, and encouraged him to learn music properly.
In 2002, he was adjudged as the best singer of the year for "Raja Geetham", a musical competition conducted by Raj TV, and received the award in the presence of legendary musicians including M. S. Viswanathan, S. P. Balasubrahmanyam and A. R. Rahman.
[7] Mukesh Mohamed's debut in playback singing was for the song "Thee Kuriviyai" in the 2004 Tamil film Kangalal Kaidhu Sei.
He is popularly known for his singing of “Ullathil nalla ullam”, an emotionally loaded hit song from the 1964 Tamil movie Karnan in live orchestras across the world.