Also, his and Kyoya Hibari's character CD entitled "Sakura addiction", peaked at seventh place on the Oricon charts.

Appearing as the series' first antagonist, Mukuro is not averse to disposing of those who get in his way, and is not easily intimidated, usually speaking to others in a very direct and arrogant manner.

When Mukuro killed his captors, he offered Chikusa and Ken, who were also victims of experimentation, a chance to join him in his quest to destroy the world.

[15] Even after becoming the Vongola's Mist Guardian, Mukuro still claims to no longer be part of the Mafia, having been exiled from it, and continues to view the organization with great contempt.

The skills granted from the individual paths varies from enhancing his physical and mind-controlling abilities, as well as his power of his illusions, to enabling him to control and summon animals.

[19] After arriving in Japan from Italy, and enrolling in Kokuyo Middle School, ten days prior to their first appearance, Mukuro, Chikusa, and Ken, started a gang made up of Mafia criminals, and began their quest to find the Vongola's tenth generation boss.

After having his subordinates attack the strongest students in Namimori Middle School, he successfully draws out the tenth boss, Tsunayoshi Sawada.

[11] Whilst strolling in his illusions, he comes upon Chrome Dokuro, who was on the verge of death, and possesses her, saving her life with illusionary organs.

After Tsuna's group returns to the past, Mukuro is lured into possessing Chrome when Daemon Spade endangers her life.

During the first day of the Representative battle, Mukuro's team able to defeat five people within ten minutes, thanks to Verde's machine that able to change illusion into reality.

At the fourth day of Representative Battle, he, Dino, Squalo, Xanxus, Byakuran, and Hibari confronts Jager, preventing him from helping his teammates while Tsuna, Enma, and Basil defeats them one by one.

Jager succeeded in defeating Dino, Squalo, Xanxus, and Byakuran, leaving only Mukuro and Hibari to fight until Tsuna arrived to help.

[28] On November 7, 2007, Pony Canyon released a character CD entitled "Sakura addiction", which features both Mukuro and Hibari.

[32] In the third poll of the series, Mukuro ranked as the third most popular male character, losing to Tsunayoshi Sawada and Kyoya Hibari, who took second and first place, respectively.

The Japanese music distributor Recochoku has made two annual survey of which anime characters that people would like to marry.

[37] A plethora of merchandise has been released in Mukuro's likeness including key chains,[38] plush dolls,[39] and action figures.

Leroy Douresseaux of comicbookbin.com views him as "murderous and supernaturally powerful," as well as being a "slippery and formidable villain" by the way he attacks Tsuna and his friends.

He also praises Akira Amano for the originality of Mukuro's techniques, viewing it as "one of the most interesting ideas I've seen," and making him, along with Tsuna, the "real winners overall" of volume 9.