[1] Indigenous peoples have lived in this area for thousands of years due to the abundance of water in the river valley.

Extensive ancient cave paintings can be found in the nearby Sierra de Guadalupe mountains.

In 1702, Jesuit Father Juan Maria de Salvatierra identified the valley of today's Mulegé as a place for a mission to the Indians.

It was not until 1754 that Father Francisco Escalante started the construction of the mission, called Misión Santa Rosalía de Mulegé.

Years later, many other Jesuit fathers came into today's area of Mulegé to bring the Catholic faith and convert the natives to Catholicism.

The entire peninsula of Baja California is an area with one of the lowest precipitation rates in the world.

Rain is rare but usually occurs between December and March, and hurricanes are occasionally a major threat to the Mulegé area.

By land, Mulegé is accessible by Federal Highway 1, which runs from Tijuana at the US-MX border to Cabo San Lucas.