The El Vizcaíno Biosphere Reserve is located in the municipality, between the Pacific Ocean and the Gulf of California.

With a landmass of over 24,930 km2 (9,625 sq mi),[3] it is the largest wildlife refuge in Mexico and borders on the northern edge of the Valle de los Cirios Protected Area of Flora and Fauna.

In 1885, the French mining company El Boleo began its operations and built the town of Santa Rosalía; the first copper smelting furnace was installed in 1886.

Guerrero Negro was founded in 1957 on the Pacific Coast to supply the demand of salt in the western United States.

[6] As of March 1, 2021, the municipality reported 1,188 recoveries, 46 active cases, and 109 deaths from the COVID-19 pandemic in Mexico.

The municipality is home of two jesuit missions of the XVII century in Mulegé and San Ignacio, these two towns also have oasis, which are a popular sightview in the desert.

Santa Rosalía it's another spot, famous for being an historical mining town and their many buildings in French architectural style.

[8] Mulegé also contains the most famous rock art sites in Baja California Sur and Mexico.

The best known sites are located at Sierra de San Francisco, although many of them requires trips by mule of 3–5 days.

[2] Mulegé is crossed by the Carretera Transpeninsular (Mexican Federal Highway 1), which runs from Tijuana to Cabo San Lucas.