The club has achieved minimal honours in its history having spent most of its existence playing in the amateur divisions of France.

Mulhouse has served as a springboard for several football players and managers, most notably Arsène Wenger and Raymond Domenech.

In the managerial role Wenger is known for his time at English club Arsenal, but prior to that had successful stints at Nancy, AS Monaco, and Nagoya Grampus.

The 1932 regional title was parlayed into a win in the Coupe Sochaux, also known as the Challenge Peugeot, one of the predecessors of the national championship competition first staged the following season.

With the onset of World War II and the re-conquest of Alsace by Germany, FCM returned to that country's football competition in the regional first division Gauliga Elsaß in 1941.

They quickly became the dominant side there capturing titles in 1941, 1943, and 1944, but were not able to follow up with any success in the German national championship playoff rounds, being eliminated in the early going on each occasion.

However, its performance improved in the 1980s, and FCM became a solid second division side, earning single-season turns in the top flight in 1982–83 and 1989–90.

[2] On 12 July 2022, the Grand Est league announced that Mulhouse were to be relegated to Régional 1 for financial reasons, subject to appeal.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.