One of the pioneers of Indo-Anglian fiction, he, together with R. K. Narayan, Ahmad Ali and Raja Rao, was one of the first India-based writers in English to gain an International readership.

Anand is admired for his novels and short stories, which have acquired the status of classics of modern Indian English literature; they are noted for their perceptive insight into the lives of the oppressed and for their analysis of impoverishment, exploitation and misfortune.

The novel follows a single day in the life of Bakha, a toilet-cleaner, who accidentally bumps into a member of a higher caste, triggering a series of humiliations.

Bakha searches for salve to the tragedy of the destiny into which he was born, talking with a Christian missionary, listening to a speech about untouchability by Mahatma Gandhi and a subsequent conversation between two educated Indians, but by the end of the book Anand suggests that it is technology, in the form of the newly introduced flush toilet, that may be his savior by eliminating the need for a caste of toilet cleaners.

Untouchable, which captures the vernacular inventiveness of the Punjabi and Hindi idiom in English, was widely acclaimed, and won Anand his reputation as India's Charles Dickens.

While in London, he wrote propaganda on behalf of the Indian cause alongside India's future Defence Minister V. K. Krishna Menon, while trying to make a living as a novelist and journalist.

[13] At the same time, he supported Left causes elsewhere around the globe, traveling to Spain to volunteer in the Spanish Civil War, although his role in the conflict was more journalistic than military.

Anand also delivered a series of lectures on eminent Indians, including Mahatma Gandhi, Jawaharlal Nehru and Rabindranath Tagore, commemorating their achievements and significance and paying special attention to their distinct brands of humanism.

In 1950 Anand embarked on a project to write a seven-part autobiographical novel titled Seven Ages of Man, of which he was only able to complete four parts beginning in 1951 with Seven Summers, followed by Morning Face (1968), Confession of a Lover (1976) and The Bubble (1984).