Often, an MFD will be used in concert with a primary flight display (PFD), and forms a component of a glass cockpit.
Many MFDs allow pilots to display their navigation route, moving map, weather radar, NEXRAD, ground proximity warning system, traffic collision avoidance system, and airport information all on the same screen.
MFDs were added to the Space Shuttle (as the glass cockpit) starting in 1998, replacing the analog instruments and CRTs.
Although many corporate business jets had them in years prior, the piston-powered Cirrus SR20 became the first part-23 certified aircraft to be delivered with an MFD in 1999 (and one of the first general aviation aircraft with a 10-in, flat-panel screen), followed closely by the Columbia 300 in 2000 and many others in the ensuing years.
In modern automotive technology, MFDs are used in cars to display navigation, entertainment, and vehicle status information.