Multiple evanescent white dot syndrome (MEWDS) is an uncommon inflammatory condition of the retina that typically affects otherwise healthy young females in the second to fourth decades of life.
Eye exam during the acute phase of the disease reveals multiple discrete white to orange spots at the level of the RPE or deep retina, typically in a perifoveal location (around the fovea).
[2] The etiology of multiple evanescent white dot syndrome is currently unknown but two potential origins have been postulated.
al. suggests a virus invades retinal photoreceptors through cell-to-cell transmission via either the ora serrata or optic disc margin.
[3] Alternatively, Jampol, et al. proposes an auto-immune origin in patients with certain genetic vulnerabilities to environmental triggers.