Mulukuku is a town and a municipality in the North Caribbean Coast Autonomous Region of Nicaragua.

People who lived in the remote rural areas and who were threatened by the contras, were brought to Mulukuku for safety.

The community straddled the only road in the region that connected the Department of Matagalpa with Lisawe, Siuna, and eventually Puerto Cabezas.

A large bridge crossing the Rio Tuma had been under construction and was nearly complete, when, in October 1988, Hurricane Joan struck Nicaragua.

On February 20, 2020, José Benito López Méndez, 51, leader of Ciudadanos por la Libertad ("Citizens for Liberty," an opposition political party) was kidnapped and shot six times in Mulukuku.