It operates as train number 22157 from Mumbai Chhatrapati Shivaji Maharaj Terminus to Chennai Egmore and as train number 22158 in the reverse direction, serving the states of Maharashtra, Karnataka, Telangana, Andhra Pradesh & Tamil Nadu.

Until 1997, this train used to cover 1,284 kilometres (798 mi) in 30 hours 00 mins via Renigunta -Guntakal line at 42.80 km/h (27 mph) average speed.

After Guntakal - Bangalore Line became Broad Gauge in 1997, the train was diverted to run via Bangalore, having a reversal there & covering 1,507 kilometres (936 mi) in 30 hours, running at 50 km/h (31 mph) average speed.

Journey time was made 28 hours 30 mins at average speed of 45 km/h (28 mph).

Finally on 2019, Mumbai-Chennai Mail was made a Superfast train, drastically reducing journey time to 23 hrs 30 mins at average speed of 55 km/h (34 mph).