The 10 main districts are Nagpur, Wardha, Amravati, Washim, Buldhana, Jalna, Aurangabad, Nashik, Ahmednagar and Thane.

The other 14 districts include Chandrapur, Bhandara, Gondia, Gadchiroli, Yavatmal, Akola, Hingoli, Parbhani, Nanded, Beed, Dhule, Jalgaon, Palghar and Raigad.

Apart from JNPT other seaports including Kandla MBPT, Mormugao, New Mangalore, Kochi, Chennai, Visakhapatnam and Ennore will also have indirect connectivity.

On 31 May 2017, the Government of Maharashtra incorporated 'Nagpur Mumbai Super Communication Expressway Limited', a special purpose vehicle (SPV) to manage the financial requirement for the construction and operation of this project.

The developmental objective to propose these new towns is to encourage the self-employment potential of the regional population through their primitive occupation i.e., agriculture or agro-related businesses.

The new townships will offer huge industrial land-banks with a focus on dedicated export-oriented infrastructure and integrated logistics to ease supply chain with enhanced road connectivity for domestic markets.

Following will either connect or act as an alternative to the Mumbai–Nagpur Expressway: 01/08/2023 - 17 people were dead and 3 were injured when under-construction crane had collapsed on workers in Thane in early hours of Tuesday morning.