Before the partition his father Nawab Nabi Bux Khan Bhutto was a member of the legislative assembly and had a strong political background.
He and his cousin Zulfikar Ali Bhutto fought the election of 17 March 1970 against Muhammad Ayub Khuhro and Qazi Fazlullah Ubaidullah.
[4] In May 2012, prior to the 2013 Pakistani general election, he announced his party's alliance with the Pakistan Muslim League (N) (PML-N).
Sindhi Language Bill, 1972 was introduced by the Chief Minister Mumtaz Bhutto on 3 July 1972, in the Sindh Assembly, Pakistan.
Due to the clashes, Prime Minister Zulfikar Ali Bhutto, compromised and announced that Urdu and Sindhi will both be official languages of Sindh.
On 31 March 1989, he called the workers' convention at Hyderabad Sindh and announced a new political party named 'Sindh National Front'.
[11] Mumtaz Bhutto was suffering from multiple diseases in lungs and cardiac issues and he was admitted in a private Hospital of Karachi.