The Municipality of Sežana (pronounced [sɛˈʒaːna] ⓘ; Slovene: Občina Sežana) is a municipality in the Littoral region of Slovenia, near the Italian border.

In addition to the municipal seat of Sežana, the municipality also includes the following settlements: Slavic tribes, ancestors of modern Slovenes, first settled the area in the late 6th century AD.

In the Middle Ages, the area belonged to the Duchy of Friuli and the Patriarchate of Aquileia, until it was conquered by the Counts of Gorizia in the 14th century.

In 1500, it fell under the Habsburg dominion and it was included in the County of Gorizia and Gradisca.

Notable people that were born or lived in the Municipality of Sežana include: