The territory of the Municipio extends in the south-eastern quadrant of the city, from Porta San Giovanni to the border of the Municipality of Rome, along the road axes of Via Appia Nuova and Via Tuscolana.

Its borders are: The territory of the Municipio was inhabited since prehistoric times, as shown by the excavations of the four necropolises of Osteria del Curato-Via Cinquefrondi, Lucrezia Romana, Romanina and Ponte delle Sette Miglia, with rock-out chamber tombs from the Copper Age, related to the so-called Rinaldone culture.

Meanwhile, in breach of the master plan, various unauthorized settlements arose – such as the Quadraro – as well as "hamlets" made of shacks built against the arches (on Via del Mandrione, at the Caffarella and at the Felice aqueduct, restored and demolished only in the late 1970s).

During the Nazi occupation of Rome in World War II, the inhabitants actively participated in the Resistance, to the point that on 17 April 1944 the German army, as a reprisal, carried out a mop-up in the Quadraro, deporting between 700 and 950 men to Germany.

Moving towards the boundaries of the Municipality, there is a prevalence of both extensive buildings, which have been at least partly built illegally (Quarto Miglio, Statuario, Tor Fiscale, Capannelle, Osteria del Curato, Morena, Gregna, Romanina, Vermicino, Passolombardo), as well as modern districts with greater endowments of public green (Cinecittà Est, Torre di Mezzavia, Nuova Romanina, Nuova Tor Vergata).

Its population is distributed as follows:[22] Road mobility in radial direction is ensured by Via Appia Nuova, Via Tuscolana Via Anagnina, as well as the Rome-Naples motorway, which intersect the Grande Raccordo Anulare.