The film stars Adam Sandler, Jennifer Aniston, and Luke Evans, and follows a married couple who are caught up in a murder investigation on a billionaire's yacht.

Aboard the yacht, Nick and Audrey meet Cavendish's ex-fiancée Suzi Nakamura, Quince's son Tobey, actress Grace Ballard, Colonel Ulenga, his bodyguard Sergei, Maharajah Vikram, and race car driver Juan Carlos, and, later that night, their host Malcolm Quince, Cavendish's uncle, arrives.

Audrey is furious to learn from a news broadcast that Nick is not actually a detective and that he lied about booking the trip in advance, and she leaves with Cavendish.

All of them go to Lake Como, where Nick and Audrey realize Cavendish and Suzi are still in love and perhaps the murderers planning to split the inheritance.

In June 2012, it was reported that Charlize Theron had signed on to star in Murder Mystery, a mystery-comedy then set to be directed by John Madden, from James Vanderbilt's screenplay.

Kyle Newacheck directed, still with Vanderbilt's script, and the film premiered on Netflix as part of Sandler's distribution deal.

[6] In June 2018, it was announced that Luke Evans, Gemma Arterton, David Walliams, Erik Griffin, John Kani, Shioli Kutsuna, Luis Gerardo Méndez, Adeel Akhtar, Ólafur Darri Ólafsson, Dany Boon and Terence Stamp had joined the cast.

[8][10] In late July 2018, filming began in Italy at locations including Santa Margherita Ligure, Lake Como,[11] and Milan (where most of the scenes set in Monaco were actually shot) also using vehicles and uniforms of the Carabinieri.

The site's critical consensus reads, "Murder Mystery reunites Jennifer Aniston and Adam Sandler for a lightweight comedy that's content to settle for merely mediocre.

"[18] Metacritic assigned the film a weighted average score of 38 out of 100, based on 19 critics, indicating "generally unfavorable reviews".

[19] Amy Nicholson of Variety wrote, "Murder Mystery feels as shamelessly gaudy as paste jewelry — a trinket for nights that aspire to nothing more exotic than a pizza — but Aniston sparkles like the real deal.