Filmmaker Emil Chiaberi presents a point of view that spree killings became widespread in the United States as a result of a major socio-economic shift that began during the Reagan era.

The film identifies corporate greed, income inequality, diminished job security, excessive consumerism and nearly total indebtedness as contributing factors to the sense of injustice that fuels murderous rage of some individuals.

Murder By Proxy: How America Went Postal derives its title from a phrase "murder by proxy" coined by Dr. James Alan Fox, dean of the college of criminal justice at Northeastern University in Boston and one of the experts who appear in the film.

Dr. Fox describes "murder by proxy" as a situation when an individual kills co-workers because "they are associated with the boss, an extension of the original target.

On July 8, 2010, the film premiered at Main Arts Theatre in Royal Oak, Michigan.