Murid gammaherpesvirus 4 (MuHV-4) is a species of virus in the genus Rhadinovirus.

It is a member of the subfamily Gammaherpesvirinae in the family Herpesviridae.

This species infects mice via the nasal passages and causes an acute infectious mononucleosis-like syndrome with elevated levels of leukocytes, and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells.

[2] Murid gammaherpesvirus 4 currently serves as a model for study of human gammaherpesvirus pathogenesis.

[3] Seven strains of Murid gammaherpesvirus 4 have been isolated, including the following six: