Born in Chicago, Landers began her career as a concert singer before moving to New York City to pursue acting.

[3] In 1952, Landers made her feature film debut in the comedy Bela Lugosi Meets a Brooklyn Gorilla, starring Duke Mitchell and Sammy Petrillo.

The pilot film for the new "Girlie Whirls" series, Tricky Chicks, cast Muriel Landers and Bek Nelson as chubby and slender showgirls.

[5] The next year, Landers had a supporting role in the romantic comedy Pillow Talk, starring Rock Hudson and Doris Day.

In 1962, Landers made a memorable appearance in The Twilight Zone episode "A Piano in the House", playing Marge Moore, an overweight woman who is forced to reveal her inner sadness about feeling unloved and unwanted because of her girth.

For the remainder of the decade, Landers continued with guest starring roles on The Beverly Hillbillies, My Three Sons and Hogan's Heroes.

She died of a stroke on February 19, 1977, and is interred at Forest Lawn Memorial Park, Hollywood Hills.