It covers much the same area as the Picola & District Football League but the teams tend to be the larger communities and towns.

Berrigan, Finley and Nathalia's application for admission into the MFL in 1932[3][4] was rejected and they continued to play in their existing competitions.

[11][12] Former Jerilderie player, Bill Brownless kicked 148 goals and was runner up in the 1985 O’Dwyer Medal, before making his debut with Geelong Football Club in 1986.

In 2018 Tungamah, Shepparton East and Katandra joined the Murray Football League after leaving the new merging Picola & District Football League due to their affiliation dispute with AFL Goulburn Murray.

[13] Shepparton East moved onto the Kyabram & District Football League at the beginning of the 2019 season.