If true, it would have been a strategic point on the road between Ptuj (Poetovio) in Slovenia and Carnuntum (Petronell) on the river Danube, the post between today's Vienna and Bratislava in Slovakia.

Other historians disagree, claiming that Helicanum might be today's Sveti Martin na Muri or nearby Lendava (Lendva).

In 1477, Mursko Središće was officially mentioned as an important trade post with three other places in Međimurje (Čakovec, Prelog and Nedelišće).

In 1901, even for that level of extraction a pipeline was constructed between Mursko Središće and nearby Selnica, the first one in this part of Europe.

In late 1918, Mursko Središće was added to the Kingdom of Serbs, Croats and Slovenes with the rest of Međimurje.

World War II ended the business started by Kraljić & Majhen Co., which was then nationalized and managed under the name of Međimurski ugljenokopi.

Forms of organized activities are numerous, such as tennis, basketball, association football, chess, hunting and fishing, and the radio "9A1CMS" club.

Today, Mursko Središće is the local administrative, business and trade center with industry primarily in the textile, transportation, building materials and more and more tourism.