In the Domesday Book of 1086 the village was recorded as Muselai, with the form Murselai being attested from the thirteenth century.

[2] The village was at one time a more important place; it was once a market town, by virtue of a royal charter granted in 1230, and the centre of the local deanery.

Actor David Tomlinson, who played George Banks in Mary Poppins and Mr. Emelius Browne in Bedknobs and Broomsticks, lived and raised his children in Mursley until his death on 24 June 2000.

[citation needed] There is also a grassroots cricket team called Mursley CC.

TB the teams lower order batsman scored a match winning maiden 31 runs in 5 overs to beat Stoke Hammond CC.