Since the 1980s the collection has been split between two buildings, with the fine arts housed in an 18th-century hôtel particulier and a separate Lapidary Museum in the former chapel of the city's Jesuit college on rue de la République.
Its collections also include goldwork, faience, porcelain, tapestries, ironwork and other examples of the decorative arts, along with archaeology and Asian, Oceanic and African ethnography.
In 1810 his will left his library, natural history collection and cabinet of antiquities to his birthplace of Avignon,[7] along with the necessary funds to make them accessible as an independent institution.
French artists represented include Le Lorrain, Eustache Le Sueur, Antoine Watteau, François Boucher, Charles-Joseph Natoire, Jean-Marc Nattier, Auguste Rodin, Honoré Daumier, Jean-François Millet, Eugène Boudin, Henri de Toulouse-Lautrec, Armand Guillaumin, Berthe Morisot, Paul Cézanne, Auguste Renoir, Alfred Sisley, Henri-Edmond Cross, Édouard Vuillard, Georges Rouault, Albert Marquet, Marc Chagall, André Lhote, Léonard Foujita and Jean Fautrier.
Italian artists include Domenico Beccafumi, Lorenzo Lotto, Baccio Bandinelli, Daniele da Volterra, Il Romanino, Paolo Veronese, Tintoretto, Jacopo Zucchi, Taddeo Zuccaro, Il Garofalo, Agostino Carracci, Federico Barocci, Mattia Preti, Luca Giordano, Domenico Fetti, Guercino, Alessandro Algardi, Luigi Garzi, Francesco Furini, Pier Francesco Mola, Daniele Crespi, Giovanni Niccolò Servandoni and Amedeo Modigliani.