[2] The first level of the museum presents a collection of Gallo-Roman funerary steles as well as objects taken from various excavations in Haute-Saône (including those of an important villa from the 2nd century AD).

The second level exhibits paintings and sculptures of the Middle Ages, Renaissance, and especially the 18th and 19th centuries.

[3] The most significant holdings of the museum are paintings and sculptures by Jean-Léon Gérôme (1824–1904), who was born in Vesoul.

These range from the very early Saint Vincent de Paul of 1847 to the very late self-portrait of the artist painting his statue The Ball Player of 1902.

[citation needed] Displayed along with Gérôme are by works of artists of Haute-Saône whom he trained at the École des Beaux-Arts in Paris, beginning in 1864.