Both the Villa and the museum itself are listed in the Swiss Inventory of Cultural Property of National and Regional Significance.

Once opened the Swiss Institute of Physics and Observatory donated their historic instruments to the collection.

Early director, the astronomer Margarida Archinard, was succeeded by chemist, Marc Cramer.

[4] The collections primarily comprise scientific measurement apparatus from the 17th-19th centuries including microscopes, telescopes, thermometers, etc., principally the former equipment of Genevan scientists including Saussure, Pictet, de la Rive and Colladon.

[2] Displays include practical experiments within the building and some exhibits in the surrounding park.