The museum is famous for its collection of original sculptures, glass windows, architectural fragments, as well as the building plans of Strasbourg Cathedral.

It has a considerable collection of works by Peter Hemmel von Andlau, Niclas Gerhaert van Leyden, Nikolaus Hagenauer, Ivo Strigel, Konrad Witz, Hans Baldung and Sebastian Stoskopff.

It is located in the half-Gothic, half-Renaissance core building of the Fondation de l’Œuvre Notre-Dame, and in several early Baroque timber-framed houses which surround it.

The first documentary evidence of the Strasbourg Fondation de l’Œuvre Notre-Dame, dates back to 1281, and it is still responsible for the maintenance of the cathedral.

In addition to the building plans, which have been preserved from the very beginning, they also conserve architectural artifacts such as fragments of the choir screen, which was destroyed in 1681 and the originals of the sculptures which were removed or knocked down during the French Revolution and were later replaced by copies.