One half of the museum is made up of the magnificent chambers in the late baroque, Rococo and Empire styles.

The other half offers a broad overview of the art of Alsatian porcelain, gold- and silversmith masters between 1681 and 1870 (decorative arts from the region prior to the French conquest are displayed in the nearby Musée de l’Œuvre Notre-Dame.)

After severe damage to the palace by English and American bombing on 11 August 1944, the chambers of the Prince-Bishops were restored little by little to their original condition up until the 1990s and the interior furnishings were rebuilt.

The chambers have the traditional furnishings of courtly display rooms (Gobelins tapestries, chinoiserie, wood carvings, murals, stucco decorations, trompe-l'œil, etc.

The museum displays elements of the first astronomical clock of Strasbourg Cathedral, among which the cock is said to be the world's oldest automaton.