Muso Toshmuhammad oʻgʻli was born on December 28, 1904 (January 10, 1905) in Tashkent in a poor family of a weaver, who constantly roamed with his goods in the steppe and mountainous villages of the then Russian Turkestan.

He wrote such works as: "Sacred Blood", "Navoi", "The Wind of the Golden Valley", "The Sun Will Not Fade", "The Great Way".

The writer's first major novel "Sacred Blood" (1943), is dedicated to the life of the peoples of Central Asia and Uzbekistan during the World War I.

In the 1930s Oybek worked on the creation of the image of the great philosopher, poet and political figure Ali-Shir Nava'i.

In 1939 he wrote a poem about the great poet, and in 1943 he completed a novel in which Oybek showed Navoi only as a public and statesman.

During the years of persecution of Crimean Tatars Oybek supported the writer Şamil Alâdin, helping him several times to get a job.

He translated into Uzbek such works as: "Eugene Onegin" by Pushkin, "Faust" by Goethe, "Masquerade" by Lermontov, Gorky, Homer (excerpts from "Iliad"), the epic "David of Sassoun", Belinsky and others.

The Qashqadaryo Regional Uzbek Musical Drama Theater and Termez State Pedagogical Institute were also named after him.