Musakhel[1] is a village and the center of Musakhel District, Khost Province, Afghanistan.

It is located at 33°32′00″N 69°44′00″E / 33.5333°N 69.7333°E / 33.5333; 69.7333 at 1835 m altitude.

The town is located within the heartland of the Ahmadzai tribe of Ghilji Pashtuns.

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