It is not a major transfer station, and only the slowest services on the Chūō Rapid Line stop at Musashi-Sakai.

The area around Musashi-Sakai has the standard commercial activity common to suburban Tokyo train stations, with branches of the Ito Yokado department store, JR-owned Hotel Mets, and the Tokyo-Mitsubishi UFJ Bank, as well as a shopping street with many restaurants and small shops on the north side.

It is the nearest train station to the International Christian University and the National Astronomical Observatory of Japan headquarters.

Tama (formerly Tamabochimae), the second stop down on the Seibu Tamagawa Line, serves The American School in Japan, Nogawa Park, Tokyo University of Foreign Studies, and other institutions.

Media related to Musashi-Sakai Station at Wikimedia Commons