It joins the Delaware at Riegelsville, approximately 10 mi (16 km) south of Phillipsburg.

The river does not flow through any large population center and has been the site of relatively little industrial development throughout its history.

The local industry declined by the middle of the 19th century after the building of the former Morris Canal, the course of which ran along the upper river, to bring coal from Pennsylvania to northern New Jersey.

Human habitation in the Musconetcong Valley can be traced back approximately 12,000 years to the end of the last ice age.

The average flow over the time recorded for the gauge at Bloomsbury is approximately 244 cfs.