There are also sections that show the literary works of Nicolás Avellaneda, his presidential successor and about the revolution caused by the federalization of Buenos Aires in 1880, when the national government had to abandon its location in downtown Buenos Aires and move to the building where the museum is today in Belgrano, then the outskirts of the city.

The building is an Italian-style townhouse, built in 1873 as planned by Juan Antonio Buschiazzo, one of the architects brought in the mid-19th century to Argentina by Bernardino Rivadavia.

At the time, it housed the executive, legislative and judicial powers of the federal government, when they had to leave Buenos Aires.

On 28 July of that year, the mansion was dedicated by presidential decree of then president Roberto Marcelino Ortiz, after a proposal of then head of the Historical Museums Commission Ricardo Levene.

The museum's collection contains furniture, and various sets of cutlery obtained by the president during his travels.