Museum de Fundatie forms part of the Hannema-de Stuers Foundation, to which Kasteel het Nijenhuis in Heino also belongs.

Its original location was Kasteel Het Nijenhuis, a 17th-century castle near the villages of Heino and Wijhe, which was the residence of museum founder Dirk Hannema.

[10][11] The museum's collection is divided over two locations: Designed by Eduard Louis de Coninck of The Hague, this former Palace of Justice was built in the neo-classicist style between 1838 and 1841.

The court building was completely revamped by architect Arne Mastenbroek during the 1980s to serve as the new office for the national planning service's information department (RPD).

[4] Among these works are paintings of Marc Chagall, Piet Mondrian, Isaac Israëls, Vincent van Gogh, Lucebert, Paul Citroen, Karel Appel, and Carel Willink, and sculptures by Antonio Canova and Gian Lorenzo Bernini.

[18][17] The museum has agreed, in 2021, to pay a compensation for the claimants representing Mr. Richard Semmel, a German Jewish industrialist from Berlin, who fled Nazi Germany in 1933, for the 1635 painting, Bernardo Strozzi’s Christ and the Samaritan Woman at the Well.

In 2013, the Dutch Restitutions Committee had previously denied the right of the claimants " on the grounds that the works are more important to the museums which house them now than they are to the heirs."

[23] Finally, following a critical review of the Restitutions Committee’s work that called for more “humanity, transparency and goodwill", the Museum de Fondatie decided to negotiate a compensation with Mr. Semmel's representatives.