As the state history museum, it focuses on artifacts and eras unique to Florida's development and on roles that Floridians have played in national and global events.

Through exhibits, educational programs, research, and collections, the Museum reflects the ways that people have shaped and reacted to their cultural and natural environments.

The Museum of Florida History operates the Knott House, built in 1843.

The Emancipation Proclamation was read from the steps of the building on May 20, 1865, declaring freedom for all slaves in the Florida panhandle.

After the Civil War, Florida's first black physician got his start working for a doctor on the premises.