The museum is housed in various buildings across Lisbon, including Pimenta Palace in Campo Grande, the Praça do Comércio in the Lisbon Baixa, and the Casa dos Bicos in Alfama, among others.

Following renovations to the palace, the Museu da Cidade (City Museum) opened in 1942, under the leadership of curator Mário Tavares Chicó.

[1] In 1962, the museum purchased Pimenta Palace to serve as its home, because of its more central location and larger facilities.

However, the museum only inaugurated the new facilities at Pimenta Palace in 1979, after more than a decade of renovations.

The Museu de Lisboa currently has the following locations:[2] The Museu de Lisboa has a vast collection of paintings, sculptures, maps, historical documents, and other objects d'art.