The Neoclassical architecture, marble interiors, and spacious, well-lit rooms attracted the attention of museum officials, who purchased the disused building and refitted it.

The post office building was added to the National Register of Historic Places in 1981 as a fine example of the Neoclassical style, and is believed to be the oldest of its type in Kearney.

Many historic artists with Nebraska connections have their work in the permanent collection, such as Alice Eliza Cleaver, Robert Henri, John Philip Falter, and Frank Rinehart.

The museum usually participates in Christmas activities put on by downtown Kearney merchants, and has hosted evening fairs where Nebraska artists and artisans sell small art objects.

The series is primarily organized and funded by the University of Nebraska at Kearney, and the visiting artists participate in creative writing classes on campus in addition to their evening readings at the museum.