[2] In 1919, the provincial museum of archaeology was moved to is current location at Santa Cruz Hospital [es], a standout example of civilian renaissance architecture in Spain.

[3] A Fine Arts section was created in 1961, and the museum was then renamed as Museo de Santa Cruz.

[3] The management (not the ownership) of the museum was transferred from the Spanish State to the regional administration of Castile-La Mancha in 1984.

The hospital was founded by Pedro González de Mendoza, archbishop of Toledo 1482-1495 and a cardinal, in order to centralize assistance to orphaned and abandoned children in the city.

The altar is located in the center and the courtyards are devised seven of which are made four and of those four, only one was finalized by Alonso de Covarrubias.

There are four galleries, which connect with the courtyards, on two floors made by Enrique Egas and in the center is the table with the altar.