The museum is located in Wrocław on the Odra riverbank, in the university's main building (Uniwersytecki Square 1) designed by de:Christoph Tausch in Baroque style.

Its architectural structure with splendid sculptural decor and paintings is regarded as one of the most valuable Baroque monuments in Poland and Central and Eastern Europe.

The museum consists of the following historical halls: The collections are largely devoted to the history of the university, from the 15th century to the present day.

The oldest collections still have descriptive fiches from the Leopoldina Academy, although the majority comes from later periods, after 1811.

Urszula Bończuk-Dawidziuk / Magdalena Palica: Art collections, in: Commemorative Book for the 200th Anniversary of the Establishment of the State University in Wrocław, ed.