Music from and Inspired by Desperate Housewives

In addition to the songs, the album includes brief dialogue excerpts from the series.

Two official singles were released from the compilation, both of which were moderate successes.

The lead, "Shoes", which was recorded by Canadian country pop singer Shania Twain, received mixed to negative reviews but became a minor success, peaking as high as number 29 on both the Billboard Hot Country Songs and Radio & Records Country Top 50 charts.

While never released in the United States, the song "God Bless the American Housewife" (re-made in Canada as "God Bless the Canadian Housewife") by SHeDAISY became a minor top-20 hit on the Radio & Records Canada Country Top 30 chart.

The Canadian edition instead appends five and a half minutes of silence to track 21, then adds "God Bless the Canadian Housewife" and "Wisteria Lane" as separate tracks.