In college, he started joining organizations where he could express his political views like the Philippine Muslim Nationalist League.

In 1969, Sema worked as technical assistant of the Student's Affairs of the Commission on National Integration (CNI).

He attended numerous local and international conferences including the Pledging Session Conference in Paris, France and to the Technical Discussion Meeting of the Department of Finance-World Bank in Washington D.C., United States as a delegate representing the ARMM.

Sema served as vice mayor of Cotabato City and presiding officer of the Sangguniang Panlungsod from 2010 up to 2013.

[10] On March 8, 2022, Sema was appointed to head the Ministry of Labor and Employment of the Bangsamoro regional government under Chief Minister Murad Ebrahim, succeeding his nephew, Romeo.