He assumed office on 28 February 2020 after the docket was handed over to him by the previous cabinet secretary for Health, Sicily Kariuki.

[2] He hit the airwaves at the onset of the COVID-19 pandemic when the first case was confirmed in Nairobi on 12 March 2020 Archived 2021-02-11 at the Wayback Machine following the outbreak in Wuhan, China in December 2019.

Between 1987 and 1989 he was working with the Standard Media Group's advertising department where he rose to the position of commercial director of the institution.

[5] Kagwe's political journey began in the year 2002 when he became the fifth member of parliament for Mukurweini Constituency[6] in Nyeri County on a National Rainbow Coalition (NARC) party ticket.

In the year 2005, Kagwe was appointed to the cabinet as the minister of Information, Communication and Technology (ICT) by the late former President Mwai Kibaki.