[3] Ahmad al-Qalqashandi who died in 1418 stated that the Mutayr tribe belongs to Ghatafan who are descendants of Ishmael son of Abraham (the father of Arabs).

[5][6] DNA tests for samples taken by male participants belonging to Mutayr Tribe has confirmed that they are sharing the same haplogroup, and a common ancestor.

[3] By the 20th century, Mutayr's tribal lands extended from the highlands east of Medina, through the region of Al-Qasim, to the borders of Iraq.

Later, a Mutayri contingent, led by Al-Dewish, joined with other sections of the Ikhwan in the conquest of the Hejaz on behalf of Ibn Saud in 1924.

The Ikhwan sought to take over the newly conquered provinces for themselves and claimed that Ibn Saud had abandoned the true faith by refraining from attacking the European-ruled territories of Iraq and Syria.

Ibn Saud, however, defeated the rebels at the Battle of Sabilla in northeastern Nejd, and Al-Dewish sought with the British in Iraq.