Over time, several other civilizations came to power in the ancient town and surrounding district: the Kambojas, the Daradas, the Kekayas, the Madras, the Pauravas, the Yaudheyas, the Malavas and the Kurus.

After the fall of the Achaemenid Empire in 331 BCE, Alexander the Great marched into the present-day Punjab province with an army of 50,000 men.

In 997 CE, Sultan Mahmud Ghaznavi took over the Ghaznavid Empire, and, in 1005, conquered the Shahis in Kabul, which granted him power over the Punjab region.

The location of the present-day town became predominantly Muslim during this time because of the arrival of missionary Sufis whose dargahs still persist in the area.

[6] The place was also referred to as Kala Pani (Black Water), as it is located between two rivers: the Indus and the Chenab.

The area around the city is a flat alluvial plain and is ideal for agriculture, with many citrus and mango farms.

Muzaffargarh is connected by rail with all parts of Pakistan, as it lies on the branch track between Multan, Mianwali, and Attock.

According to the Wall Street Journal, the Pakistan Atomic Energy Commission (PAEC) plans to install three nuclear reactors at Muzaffargarh.

The plant operates on fuel but The Russian company has signed an agreement to provide imported coal to run thermal units.

At first, the upgradation of the thermal power plant was included in CPEC projects but in 2017, China excluded it from the agreement due to unclear reasons.

Fayyaz Park is located near Katchehry Chowk beside the National Bank Main City branch.