He also served as member of Parliament in the National Assembly from 2013 to 2017 after being nominated by the Orange Democratic Movement Party to represents special Interest Groups.

Mwaura served as a senior adviser to former Prime Minister Raila Odinga from 2010 to 2012 on Public Policy on Special Interest Groups.

Many ignorantly attributed his albinism as having caused by severe burns from hot water, and opined that a total blood transfusion could reverse his disability.

This was because both the grandmother Mary Wajiku and Isaac's mother used to work as casual labourers at the coffee farm of the local Member of Parliament then, Arthur Kinyanjui Magugu.

In that same year, Isaac emerged the top pupil in the Kenya Certificate of Primary Education (KCPE) in his school in 1996, and also the best in Kiswahili Public Speaking nationally.

In 2016, Mwaura was conferred with an honorary Doctor of Philosophy in Humanities (Honoris Causa) from UGCI- USA for his immeasurable contribution in serving the marginalized and minorities in Kenya.

He then joined National Council for Persons with Disabilities (NCPWD) as the Head of Communications and Public Relations before rising to the position of deputy director of Programmes in the same state agency.

Subsequently, he and others successfully lobbied the Joint Admission Board of Kenya to admit students with special needs who had met the minimum required grade for university placement.

[26] Through ASK, persons with albinism in Kenya are provided with free sunscreen lotions, prescription glasses and protective clothing in order to shield them from harmful solar radiation.

[29][30] Mwaura has led sustained campaigns against stigmatization, discrimination, violence and persecution of persons with albinism in Kenya and East Africa.

Fallacies and misconceived ideas about promise of wealth, health and success have led to kidnapping, trafficking and brutal murder of innocent men, women and children.

[31] Mwaura, who adopted and educates two young children with albinism - Bianca Chacha and Gabriel Kinyanjui - who had been abducted for ritual killings in 2016 but salvaged, appealed to the East Africa Community.

[32] "The heads of state from East Africa should come up with a policy statement on the plight of persons with albinism in the region which has reached alarming levels.

Mwaura, in a press conference in Nairobi on 24 August 2019 apportioned blame to heads of state in Africa for their passivity and failure in safeguarding rights and freedoms of persons with albinism.

Mwaura asked, "How comes that Africa, which suffered from many years of slavery, is the same that is leading in the killings of Persons with Albinism and discrimination based on skin colour?"

[39] Furthermore, Mwaura in 2018 petitioned Central Bank of Kenya to ensure the new currency is accessible to persons with visual impairments, which was adopted and implemented.

[41] In 2016, Mwaura was honoured with the First Class: Chief of the Burning Spear (CBS) by Kenya's President Uhuru Kenyatta for his immense disability advocacy and parliamentary achievement.

[44] Mwaura had met Lupita in 2006, and through this encounter, she introduced him to her father, Professor Peter Anyang' Nyong'o, the governor of Kisumu County, who later became his political mentor and the first patron of Albinism Society of Kenya.

[citation needed] Mwaura was born with Albinism, a genetic condition that causes the skin, hair and eyes to have little or no melanin pigment.

Albinism is non-contagious condition that results from biological inheritance of genetically recessive alleles (genes) from both parents and it is characterised by the absence of tyrosinase, an enzyme involved in the production of melanin.

[45] Persons with albinism often face social and cultural challenges (including threats), as the condition is often a source of ridicule, discrimination, or even fear and violence.

[46] The majority of people with albinism in East Africa live in marginalized social conditions and in a state of economic vulnerability because, apart from having a different physical appearance and having visual impairments, they cannot actively take part in agricultural work due to their sensitivity to the sun, and this effectively excludes them from engaging in the major productive activity in most rural areas.

[47] In African countries such as Tanzania and Burundi, there has been unprecedented rise in witchcraft-related killings of people with albinism in recent years, because their bodies are used in portions sold by witch doctors.

Subsequently, he and other leaders organised a major strike that ousted the Vice-Chancellor Professor George Eshiwani who was serving an illegal term at Kenyatta University.

After completing his undergraduate course at Kenyatta University, Mwaura joined Orange Democratic Movement (ODM) party as a member in 2006 and rose ranks to become the Secretary of Disability Affairs.

[59] During 2007 Kenya's General election, Mwaura was instrumental in mobilizing voters with disabilities and campaigning for the ODM presidential candidate Raila Odinga.

Chaos erupted and an ambush of mafia-like men in black suits, infamously referred as 'men-in-black', stormed the gymnasium and destroyed ballot papers and boxes.

[62] Nevertheless, Mwaura conceded defeat, stating that his political debut had 'helped fight stigma and discrimination, break glass ceiling, push the awareness and inclusion agenda forward, and inspire many other people in Kenya and beyond to stand up and be counted.

[64] On a Facebook post, Mwaura reported about being harassed and discriminated by virtue of his albinism by the Secret Service agents during a UN General Assembly forum in New York in September, 2019.

Mwaura was again to suffer more humiliation in the same event as he was initially denied access to meet President Uhuru Kenyatta and other colleagues at Hotel Latte.