The series follows the three as they take on supernatural forces and have adventures, with occasional help from fellow vampires Rory (Cameron Kennedy) and Erica (Kate Todd), while dealing with the troubles of regular high school life.

The film was released on DVD in the United Kingdom on June 25, 2012, with the premiere episode of the series, "Lawn of the Dead".

The first-season finale on Teletoon had an extra scene added to coincide with the online companion game results, which Disney Channel did not air.

[10][11] A 13-episode second season of the show was greenlit by Fresh TV, and was originally revealed by Vanessa Morgan on her official, personal Twitter.

[14] It was later revealed by Vanessa Morgan on Twitter that it would premiere June 29, 2012, at 8 pm Eastern Time on Disney Channel.

The first season episodes of My Babysitter's a Vampire that aired on Disney Channel in the United States in June 2011, averaged 3.7 million viewers and was the number 1 cable show among kids 2–11 in its time period (weekdays 7 pm/6c).

It was creator-driven, with a strong point of view that was relevant and connected with our core audience in a big way," when he was asked about top-performing acquired programming.

[18] In May 2011, prior to first-season episodes of My Babysitter's a Vampire airing on Disney Channel in the United States, and after certain episodes aired as sneak peeks on Teletoon/Télétoon (in Canada); Secret Location, with support from the Bell Broadcast and New Media Fund, began developing a video game for Teletoon and MBAV called "Humans vs. Vampires in 3D".

[3] Humans vs. Vampires is a modern spin on classic arcade-style games like Street Fighter and Mortal Kombat.

[49] In the mobile version, Ethan's sister Jane and a character from season 2 named Boltz are added to the game.

[50] The game was free to download in the App Store under the title "Humans VS Vampires", but was quietly removed a few years later.