It is a parody of well-known independent films,[1] such as My Big Fat Greek Wedding, Memento, Swingers, Pulp Fiction, Magnolia, Amélie, Reservoir Dogs, Pi, The Good Girl, Run Lola Run, Clerks and El Mariachi.

My Big Fat Independent Movie was eventually acquired by Anchor Bay Entertainment distribution and the film was released on DVD.

The film then cuts forward in time to two talkative hitmen, Sam (Neil Barton) and Harvey (Eric Hoffman), who mistakenly believe Johnny Vince (Darren Keefe), a hipper-than-thou swingin' hepcat and Memento Guy (Brian Krow) to band trombone player, to be the third member of their gang, assembled by their evil crime boss to pull a "botched robbery" in Las Vegas.

During the journey, the foursome encounter a variety of characters inspired by famous independent films, including a bald genius, a forgetful thug, a jogging red-head, a bound and gagged girl, rabbis on a mission, many lesbians, Project Greenlight's Pete Jones, a crazed though well-dressed mechanic]] (Clint Howard), a horny answering machine (Jason Mewes), a naive mariachi, an obnoxious practical-joking love-struck French girl, and finally Pauly Shore as himself.

My Big Fat Independent Movie was a box-office bomb, earning only $4,655 in box office receipts during its world-wide run[2] with an estimated budget of around $3,000,000.