[1] The song's lyrics potentially continue the storyline that first emerged from the three album tracks that had been released, "Jumpsuit", "Nico and the Niners" and "Levitate".

[1] However, it has not been confirmed if "My Blood" is a continuation of the story encompassing the trilogy of official music videos, but the lyrics do appear to have a maverick spirit in the third verse.

[4][5][6] The moody, groove-driven track contains R&B hooks and has a throbbing beat underpinned with robotic drums and thick funk generated by a rolling, distorted bass line.

"[1] The musical arrangement builds into an effervescent chorus where Joseph sings in a keening falsetto and repeatedly cries out, "Stay with me, my blood, you don't need to run.

[12] On August 27, 2018, an audio release of the track included one-shot video footage of frontman Tyler Joseph in a recording studio lined by guitars on the walls.

Billboard contributor Shea Lenninger called "My Blood" a fresh take on the duo's style and described its chorus as catchy.

[10] Gil Kaufman, from the same publication, quipped that "Twenty One Pilots seemed determined to show us the full breadth of their musical playbook" with the release of the single, praising Tyler Joseph's "keening falsetto that would make the Bee Gees proud.

"[1] Citing it among the "fresh tricks" found on Trench, AllMusic's Neil Z. Yeung also applauded Joseph's use of falsetto range on the track.

"[7] Complimenting its "glowing '80s chorus", Chris DeVille for Stereogum cited the song as Trench's "closest thing to a pop crossover bid".

Hinton, featuring two brothers, an older, loud, instigative troublemaker and a younger, quiet, shy and sensitive introvert whose bond is solidified by a childhood spent with an alcoholic father.

[11][10] The video focuses on the pair of siblings as children and teenagers, alternating back and forth between adolescent mischief and the childhood trauma of watching their mother in the hospital.

As he and his brother wander small-town streets, the edgier character shatters a mailbox, confronts the local group of jocks and chugs from a flask.

[11][3] The situation between them and the school jocks intensifies at a Halloween party, where the siblings arrive dressed in skeleton outfits and dance to a house-band, portrayed by Twenty One Pilots.